Tumor–stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c‐Met pathway
T Ide, Y Kitajima, A Miyoshi, T Ohtsuka… - … journal of cancer, 2006 - Wiley Online Library
The hypoxic environment in tumor is reported to play an important role in pancreatic cancer
progression. The interaction between stromal and cancer cells also contributes to the
malignant behavior of pancreatic cancer. In the present study, we investigated whether
hypoxic stimulation affects stromal as well as pancreatic cancer cells. Our findings
demonstrated that hypoxia remarkably elevated the HIF‐1α expression in both pancreatic
cancer (PK8) and fibroblast cells (MRC5). Hypoxic stimulation accelerated the invasive …
progression. The interaction between stromal and cancer cells also contributes to the
malignant behavior of pancreatic cancer. In the present study, we investigated whether
hypoxic stimulation affects stromal as well as pancreatic cancer cells. Our findings
demonstrated that hypoxia remarkably elevated the HIF‐1α expression in both pancreatic
cancer (PK8) and fibroblast cells (MRC5). Hypoxic stimulation accelerated the invasive …
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